Campaña Araceli G, Fuentes Noelia, Gómez-Bengoa Enrique, Mateo Cristina, Oltra J Enrique, Echavarren Antonio M, Cuerva Juan M
Department of Organic Chemistry, Faculty of Sciences, Campus Fuentenueva s/n, University of Granada, E-18071 Granada, Spain.
J Org Chem. 2007 Oct 12;72(21):8127-30. doi: 10.1021/jo701354c. Epub 2007 Sep 19.
Sodium tetramethoxyborate, easily prepared by reaction of inexpensive sodium borohydride with methanol, possesses a suitable combination of a Lewis base and a Lewis acid to catalyze Michael reactions at room temperature under practically neutral conditions. This reaction provides good to excellent yields of Michael addition products from a broad scope of Michael donor and Michael acceptor reagents.
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