Poonnoose P M, Thomas R, Keshava S N, Cherian R S, Padankatti S, Pazani D, Kavitha M L, Devadarasini M, Bhattacharji S, Viswabandya A, John J A, Macaden A S, Mathews V, Srivastava A
Department of Orthopaedics, Christian Medical College, Vellore 632004, India.
Haemophilia. 2007 Sep;13(5):620-6. doi: 10.1111/j.1365-2516.2007.01508.x.
Joint morbidity in haemophilia has traditionally been measured using clinical and radiological scores. There have been no reliable, validated tools for the assessment of functional independence in persons with haemophilia till recently. The Functional Independence Score in Haemophilia (FISH) has been developed as a performance based assessment tool to address this need. The FISH is designed to measure the patient's independence in performing activities of daily living (grooming and eating, bathing and dressing), transfers (chair and floor), and mobility (walking, step climbing and running). On assessment of its psychometric properties in 63 patients with haemophilia (mean age 14 years), FISH was found to have good internal consistency (Cronbach's alpha of 0.85). It had moderate correlation with the World Federation of Hemophilia clinical score (r = -0.61), and a correlation with the Pettersson score of -0.38. It had good correlation with other self-rated functional scores, such as the Stanford Health Assessment Questionnaire (r = -0.75); the Western Ontario and McMaster Universities Osteoarthritis Index (r = -0.66) and the Haemophilia Activities List (HAL) (r = -0.66). It had good reliability with a pooled intra class correlation of 0.98. On assessing responsiveness following treatment of flexion deformities of the knee in 12 patients, the FISH showed significant changes in the score with a standardized responsiveness mean of -1.93. In conclusion, the FISH was found to be a reliable and valid tool with good internal consistency and responsiveness to therapy, for the assessment of functional independence in persons with haemophilia.
血友病的关节发病率传统上是使用临床和放射学评分来衡量的。直到最近，还没有可靠的、经过验证的工具来评估血友病患者的功能独立性。血友病功能独立性评分（FISH）已被开发为一种基于表现的评估工具，以满足这一需求。FISH旨在衡量患者在进行日常生活活动（梳洗和进食、洗澡和穿衣）、转移（从椅子到地面）和移动（行走、上台阶和跑步）方面的独立性。在对63名血友病患者（平均年龄14岁）进行心理测量学特性评估时，发现FISH具有良好的内部一致性（克朗巴哈系数为0.85）。它与世界血友病联盟临床评分有中度相关性（r = -0.61），与彼得松评分的相关性为-0.38。它与其他自评功能评分有良好的相关性，如斯坦福健康评估问卷（r = -0.75）；西安大略和麦克马斯特大学骨关节炎指数（r = -0.66）以及血友病活动清单（HAL）（r = -0.66）。它具有良好的可靠性，组内相关系数合并为0.98。在评估12例膝关节屈曲畸形患者治疗后的反应性时，FISH评分有显著变化，标准化反应性平均值为-1.93。总之，FISH被发现是一种可靠有效的工具，具有良好的内部一致性和对治疗的反应性，可用于评估血友病患者的功能独立性。
