Gellad Walid F, Haas Jennifer S, Safran Dana Gelb
Division of General Medicine and Primary Care, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02120-1613, USA.
J Gen Intern Med. 2007 Nov;22(11):1572-8. doi: 10.1007/s11606-007-0385-z. Epub 2007 Sep 20.
Nonadherence to prescription drugs results in poorer control of chronic health conditions. Because of significant racial/ethnic disparities in the control of many chronic diseases, differences in the rates of and reasons for medication nonadherence should be studied.
DESIGN/SETTING: Cross-sectional national survey, 2003.
Medicare beneficiaries > or = 65 years of age, who reported their race/ethnicity as white, black, or Hispanic, and who reported taking at least 1 medication (n = 14,829).
Self-reported nonadherence (caused by cost, self-assessed need, or experiences/side effects) during the last 12 months.
Blacks and Hispanics were more likely than whites to report cost-related nonadherence (35.1%, 36.5%, and 26.7%, respectively, p < .001). There were no racial/ethnic differences in nonadherence caused by experiences or self-assessed need. In analyses controlling for age, gender, number of chronic conditions and medications, education, and presence and type of prescription drug coverage, blacks (odds ratio [OR] 1.38; 95% confidence interval [CI] 1.08-1.78) and Hispanics (1.35; 1.02-1.78) remained more likely to report cost-related nonadherence compared to whites. When income was added to the model, the relationship between cost-related nonadherence and race/ethnicity was no longer statistically significant (p = .12).
Racial/ethnic disparities in medication nonadherence exist among seniors, and are related to cost concerns, and not to differences in experiences or self-assessed need. Considering the importance of medication adherence in controlling chronic diseases, affordability of prescriptions should be explicitly addressed to reduce racial/ethnic disparities.
不遵医嘱服用处方药会导致慢性健康状况的控制效果较差。由于在许多慢性疾病的控制方面存在显著的种族/族裔差异,因此应研究药物不依从率及其原因的差异。
1)确定老年人中药物不依从率及其原因是否因种族/族裔而异;2)评估种族/族裔与不依从之间的任何关联是否受到处方药覆盖范围和收入的调节。
设计/背景:2003年全国横断面调查。
年龄≥65岁的医疗保险受益人,他们将自己的种族/族裔报告为白人、黑人或西班牙裔,且报告服用至少一种药物(n = 14829)。
过去12个月内自我报告的不依从情况(由费用、自我评估的需求或经历/副作用引起)。
黑人和西班牙裔比白人更有可能报告与费用相关的不依从情况(分别为35.1%、36.5%和26.7%,p < 0.001)。因经历或自我评估需求导致的不依从情况不存在种族/族裔差异。在控制了年龄、性别、慢性病和药物数量、教育程度以及处方药覆盖范围的存在和类型的分析中,与白人相比,黑人(优势比[OR] 1.38;95%置信区间[CI] 1.08 - 1.78)和西班牙裔(1.35;1.02 - 1.78)仍更有可能报告与费用相关的不依从情况。当将收入纳入模型时,与费用相关的不依从情况与种族/族裔之间的关系不再具有统计学意义(p = 0.12)。
老年人中存在药物不依从方面的种族/族裔差异,且与费用担忧有关,而非与经历或自我评估需求的差异有关。考虑到药物依从性在控制慢性疾病中的重要性,应明确解决处方药的可负担性问题,以减少种族/族裔差异。