TrkC：乳腺癌中的一种新的预测标志物？

TrkC: a new predictive marker in breast cancer?

作者信息

Blasco-Gutiérrez María Jesús, José-Crespo Isabel Julia San, Zozaya-Alvarez Enrique, Ramos-Sánchez Rafael, García-Atarés Natividad

机构信息

Pathology Department, Facultad de Medicina-Universidad de Valladolid, Valladolid, Spain.

出版信息

Cancer Invest. 2007 Sep;25(6):405-10. doi: 10.1080/07357900701206349.

DOI:10.1080/07357900701206349

PMID:17882651

Abstract

Available data involve neurotrophins and their receptors in carcinomas. Quantitative evaluation of these molecules in these tumors might be useful as prognostic marker and eventual treatments. Our study on 40 mammary tumors tries to correlate expression of these molecules and prognosis. Immunohistochemistry for NGF, BDNF, NT3, TrkA, TrkB, TrkC, and p75 was used. Patient's age, histopathology, Bloom-Richardson grading, estrogen and progesterone receptors, Ki-67 index, HER-2, p53 were evaluated. Statistics found inverse relationship between grading and TrkC expression. We found significantly higher TrkC expression in Grade I than in Grade III tumors. Rise in TrkC expression could indicate good prognosis.

摘要

现有数据涉及癌组织中的神经营养因子及其受体。对这些肿瘤中这些分子进行定量评估可能作为预后标志物及最终治疗手段。我们对40例乳腺肿瘤的研究试图将这些分子的表达与预后相关联。采用了针对神经生长因子（NGF）、脑源性神经营养因子（BDNF）、神经营养因子3（NT3）、酪氨酸激酶受体A（TrkA）、酪氨酸激酶受体B（TrkB）、酪氨酸激酶受体C（TrkC）和p75的免疫组织化学方法。评估了患者的年龄、组织病理学、布卢姆-理查森分级、雌激素和孕激素受体、Ki-67指数、人表皮生长因子受体2（HER-2）、p53。统计学发现分级与TrkC表达之间呈负相关。我们发现I级肿瘤中的TrkC表达显著高于III级肿瘤。TrkC表达升高可能预示着良好的预后。