Patil Asha B, Nadiger Shobha, Chandrasekhar M R, Halesh L H, Kumar Mahesh
Department of Microbiology, Karnataka Institute of Medical Sciences, Hubli.
Indian J Pathol Microbiol. 2007 Jul;50(3):671-3.
To report an interesting case of meningitis caused by Listeria monocytogenes meningitis in an HIV seropositive individual.
MATERIALS & METHODS: A previously healthy 45 years old HIV seropositive man, presented with atypical clinical features of meningitis. Blood and Cerebrospinal fluid (CSF) were obtained for biochemical and microbiological investigations.
CSF analysis showed pleocytosis with lymphocytic predominance. Gram stain of CSF was negative; however culture yielded growth of gram positive bacilli with tumbling motility. Based on relevant biochemical tests the isolate was identified as Listeria monocytogenes. Patient was treated with i.v. ampicillin and recovered completely.
Listeriosis is relatively rare in HIV/AIDS among the immunodeficient populations. Atypical clinical and laboratory findings make the diagnosis difficult and these infections may go undiagnosed. Since it is easily treated with readily available antibiotics, it is important to diagnose them at the earliest and thereby prevent treatment failure.
报告一例HIV血清阳性个体发生的由单核细胞增生李斯特菌引起的脑膜炎的有趣病例。
一名既往健康的45岁HIV血清阳性男性，表现出非典型的脑膜炎临床特征。采集血液和脑脊液进行生化及微生物学检查。
脑脊液分析显示细胞增多，以淋巴细胞为主。脑脊液革兰氏染色为阴性；然而培养物中生长出具有翻滚运动性的革兰氏阳性杆菌。基于相关生化试验，分离株被鉴定为单核细胞增生李斯特菌。患者接受静脉注射氨苄西林治疗并完全康复。
在免疫缺陷人群的HIV/AIDS中，李斯特菌病相对罕见。非典型的临床和实验室检查结果使诊断困难，这些感染可能未被诊断出来。由于它很容易用现有的抗生素治疗，尽早诊断并从而防止治疗失败很重要。
