Geminiani M, Aimoni C, Scanelli G, Pastore A
ENT Clinic, Clinical Internal Medicine, University Hospital of Ferrara, Italy.
Acta Otorhinolaryngol Ital. 2007 Jun;27(3):123-5.
Aim of this study was to investigate any eventual quantitative variations in the serological concentration of parathormone in a homogenous sample of patients suffering from laryngeal squamous cell carcinoma who underwent only surgery. A total of 12 patients (2 female, 10 male), aged between 58 and 76 years, were treated between June 2002 and June 2003. The patients were all affected by T2-T3 laryngeal squamous cell carcinoma. Serum intact parathyroid hormone and calcaemia were measured pre- and post-operatively. Of these patients, 2 underwent total laryngectomy (including thyroid isthmectomy), 5 patients received partial supraglottic laryngectomy, while the remaining 5 were submitted to supracricoid laryngectomy. Results showed a progressive regression of parathyroid hormone level, in only one case and was not, however, below normal limits. Contrary to data reported in the literature, this study indicated that the incidence of hypoparathyroidism following laryngeal surgery, even in radical surgical approaches, proved to be closer to zero.
本研究的目的是调查仅接受手术治疗的喉鳞状细胞癌患者同质样本中甲状旁腺激素血清浓度的任何最终定量变化。2002年6月至2003年6月期间，共治疗了12例患者（2例女性，10例男性），年龄在58岁至76岁之间。所有患者均患有T2 - T3期喉鳞状细胞癌。术前和术后测量血清完整甲状旁腺激素和血钙水平。这些患者中，2例行全喉切除术（包括甲状腺峡部切除术），5例接受部分声门上喉切除术，其余5例行环状软骨上喉切除术。结果显示，仅1例甲状旁腺激素水平呈进行性下降，但未低于正常范围。与文献报道的数据相反，本研究表明，即使是根治性手术方法，喉手术后甲状旁腺功能减退的发生率也接近于零。
