Thorp M A, Levitt N S, Mortimore S, Isaacs S
Department of Otolaryngology, University of Cape Town, South Africa.
Clin Otolaryngol Allied Sci. 1999 Apr;24(2):104-8. doi: 10.1046/j.1365-2273.1999.00214.x.
The proximity of the thyroid and parathyroid glands to the larynx and hypopharynx puts them at risk from treatment of squamous cell carcinoma (SCC) of this region. Consequently parathyroid and thyroid function was evaluated in patients surviving at least 5 years following treatment of primary SCC of the larynx or hypopharynx. Twenty-eight patients, initially treated from 1990 to 1992, were assessed and divided into four groups according to treatment received. Hypoparathyroidism (partial and hypocalcaemic) occurred in 88% and hypothyroidism (clinical and subclinical) in 50% in Group 1 (radiotherapy only) Group 2 (salvage laryngectomy for failed radiotherapy) had 66% hypoparathyroid and 33% hypothyroid. Group 3 (surgery + radiotherapy combined) had 89% hypoparathyroid and 89% hypothyroid. Group 4 (surgery only) had 63% hypoparathyroid and 63% hypothyroid. Significant endocrine hypofunction therefore occurs following the treatment of laryngopharyngeal carcinoma, more so with radiotherapy and combined therapy than with surgery alone.
甲状腺和甲状旁腺与喉及下咽相邻，这使得它们在该区域鳞状细胞癌（SCC）的治疗过程中面临风险。因此，对喉或下咽原发性SCC治疗后存活至少5年的患者的甲状旁腺和甲状腺功能进行了评估。对28例于1990年至1992年接受初始治疗的患者进行了评估，并根据所接受的治疗分为四组。第1组（仅接受放疗）中，88%出现甲状旁腺功能减退（部分性和低钙血症），50%出现甲状腺功能减退（临床和亚临床）；第2组（放疗失败后行挽救性喉切除术）中，66%出现甲状旁腺功能减退，33%出现甲状腺功能减退；第3组（手术+放疗联合）中，89%出现甲状旁腺功能减退，89%出现甲状腺功能减退；第4组（仅接受手术）中，63%出现甲状旁腺功能减退，63%出现甲状腺功能减退。因此，喉咽癌治疗后会出现明显的内分泌功能减退，放疗和联合治疗比单纯手术更易导致这种情况。
