[E-钙黏蛋白在弥漫型和肠型胃腺癌中的分子表达。秘鲁利马的一份报告]
[E-cadherin molecular expresion in the diffuse and intestinal types of gastric adenocarcinoma. A report from Lima, Peru].
作者信息
Arévalo F, Monge E, Morales D
机构信息
Servicio de Anatomía Patológica, Hospital Nacional Dos de Mayo, Universidad Nacional Mayor de San Marcos, Lima, Perú.
出版信息
Rev Esp Enferm Dig. 2007 Jun;99(6):325-9. doi: 10.4321/s1130-01082007000600004.
OBJECTIVE
Signet ring carcinoma of the stomach is well known to be more aggressive and infiltrating than adenocarcinoma. Different studies have proposed that signet ring cell carcinoma would be more infiltrating because of the loss of E-cadherin expression, this cadherin is a class of protein cell membrane protein which plays an important role in cell-adhesion.
METHODS
We carried out a transversal comparative study, in order to measure the E-cadherin expression in 10 cases of signet ring cell and in 10 cases of adenocarcinoma, with help of immunohistochemistry.
RESULTS
We found a bigger expression of E-cadherin in adenocarcinomas (100%) than signet ring cell carcinoma (40%), this difference was significative using Fisher test (p = 0,011). The loss of E-cadherin would explain the bigger infiltrating capacity in comparison to adenocarcinoma.
目的
众所周知，胃印戒细胞癌比腺癌更具侵袭性和浸润性。不同研究表明，由于E-钙黏蛋白表达缺失，印戒细胞癌浸润性更强，这种钙黏蛋白是一类在细胞黏附中起重要作用的细胞膜蛋白。
方法
我们进行了一项横向比较研究，借助免疫组织化学方法测定10例印戒细胞癌和10例腺癌中E-钙黏蛋白的表达。
结果
我们发现腺癌中E-钙黏蛋白的表达（100%）高于印戒细胞癌（40%），使用费舍尔检验，这种差异具有统计学意义（p = 0.011）。E-钙黏蛋白的缺失可以解释印戒细胞癌相较于腺癌更强的浸润能力。
Zotero 插件