Lim Eun-Ju, Kang Hyun-Jung, Jung Hyun-Joo, Park Eun-Hee
College of Pharmacy, Sookmyung Women's University, Seoul 140-742, Korea.
J Pharm Pharmacol. 2007 Sep;59(9):1235-40. doi: 10.1211/jpp.59.9.0007.
4-Hydroxybenzyl alcohol (HBA), one of the well-known phenolic compounds in diverse plants, displayed a significant inhibition in the chick chorioallantoic membrane (CAM) angiogenesis assay. HBA was shown to contain an anti-inflammatory activity in carrageenan-induced air pouch model in rats and acetic acid-induced permeability model in mice. Anti-nociceptive activity of HBA was also assessed using the acetic acid-induced writhing test in mice. HBA was able to suppress production of nitric oxide (NO) and expression of inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS)-activated RAW264.7 macrophages. In the macrophages, the level of reactive oxygen species (ROS) was diminished by HBA. Taken together, HBA possesses anti-angiogenic, anti-inflammatory and anti-nociceptive activity possibly via its down-regulating activity on NO production, which may be partly responsible for the pharmacological efficacy of several folkloric medicines.
4-羟基苯甲醇（HBA）是多种植物中一种著名的酚类化合物，在鸡胚绒毛尿囊膜（CAM）血管生成试验中表现出显著的抑制作用。在大鼠角叉菜胶诱导的气囊模型和小鼠乙酸诱导的通透性模型中，HBA显示出抗炎活性。还使用小鼠乙酸诱导的扭体试验评估了HBA的抗伤害感受活性。HBA能够抑制脂多糖（LPS）激活的RAW264.7巨噬细胞中一氧化氮（NO）的产生和诱导型一氧化氮合酶（iNOS）的表达。在巨噬细胞中，HBA降低了活性氧（ROS）的水平。综上所述，HBA可能通过下调NO的产生而具有抗血管生成、抗炎和抗伤害感受活性，这可能部分解释了几种民间药物的药理功效。
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