抗孕激素RU486在大鼠体内有溶黄体作用吗？

Is the antiprogestin RU486 luteolytic in rats?

作者信息

Martin L, Crane L H

机构信息

Department of Physiology and Pharmacology, University of Queensland, Australia.

出版信息

Reprod Fertil Dev. 1991;3(5):615-9. doi: 10.1071/rd9910615.

DOI:10.1071/rd9910615

PMID:1788403

Abstract

Subcutaneous injections of RU486 on Day 1, Day 4 or Days 3 and 4 of pregnancy in rats induced abortion of the embryo and transient vaginal cornification. Nevertheless, most corpora lutea appeared to be functional at autopsy on Day 12. The same treatments in pseudopregnant rats also produced transient vaginal cornification, but did not terminate pseudopregnancy. This suggests that transient antagonism of progesterone by RU486 does not terminate function of the corpus luteum in rats and that positive feedback by progesterone is not essential for continuing luteal function in rats.

摘要

在大鼠怀孕第1天、第4天或第3天和第4天皮下注射RU486可导致胚胎流产和短暂的阴道角质化。然而，在第12天尸检时，大多数黄体似乎仍有功能。在假孕大鼠中进行相同处理也会产生短暂的阴道角质化，但不会终止假孕。这表明RU486对孕酮的短暂拮抗作用不会终止大鼠黄体的功能，并且孕酮的正反馈对于大鼠黄体功能的持续并非必不可少。