Maurelli L, Cuocolo A, Lastoria S, Brunetti A, Maurea S, Lembo G, Klain M, Caracò C, Salvatore M
Cattedra di Medicina Nucleare, II Facoltà di Medicina e Chirurgia, Università Federico II, Napoli.
Radiol Med. 1991 Dec;82(6):839-43.
The results of 131I metaiodobenzylguanidine (MIBG) and Computed Tomography (CT) scans in a group of patients with clinically suspected pheochromocytoma were evaluated and compared with biohumoral parameters. We studied 24 consecutive patients (7 M and 17 F; age range 20-66 years). 131I-MIBG scintigraphy and CT were in agreement in 19 patients (79%): of them 7 cases were true positive, and 12 were true negative. Disagreement between the two imaging techniques was observed in 5 patients (21%). In this group, one patient, with positive CT scan, had false negative MIBG study, while 4 patients with negative MIBG scan, had false positive CT. MIBG showed significantly higher (p less than 0.05) specificity (100%), positive predictive value (100%), and accuracy (96%) than CT (75%, 67%, and 83%, respectively). 131I-MIBG scintigraphy is an accurate, noninvasive technique for localizing pheochromocytoma and providing direct tissue characterization, while CT provides more accurate spatial information. In conclusion, CT and MIBG studies are complementary in the evaluation of patients with suspected pheochromocytoma.
对一组临床疑似嗜铬细胞瘤患者的131I间碘苄胍（MIBG）和计算机断层扫描（CT）结果进行了评估，并与生物体液参数进行了比较。我们研究了24例连续患者（7例男性和17例女性；年龄范围20 - 66岁）。131I - MIBG闪烁显像和CT在19例患者中结果一致（79%）：其中7例为真阳性，12例为真阴性。在5例患者（21%）中观察到两种成像技术结果不一致。在该组中，1例CT扫描阳性的患者MIBG检查为假阴性，而4例MIBG扫描阴性的患者CT为假阳性。MIBG的特异性（100%）、阳性预测值（100%）和准确性（96%）显著高于CT（分别为75%、67%和83%）（p小于0.05）。131I - MIBG闪烁显像是一种准确的、非侵入性的技术，可用于嗜铬细胞瘤的定位并提供直接的组织特征，而CT提供更准确的空间信息。总之，CT和MIBG检查在疑似嗜铬细胞瘤患者的评估中具有互补性。
