Rufini V, Troncone L, Valentini A L, Danza F M
Istituti di Medicina Nucleare, Università Cattolica del Sacro Cuore, Roma.
Radiol Med. 1988 Nov;76(5):466-70.
In order to define the diagnostic roles of MIBG imaging and CT in the detection of pheochromocytomas (pheos), the results obtained in 45 patients suspected of bearing pheo and studied with both modalities were analyzed and compared. Scintigraphy was correctly negative in 22/23 cases, correctly positive in 11/12 adrenal and 5/5 extra-adrenal pheos, and in 4/5 malignant pheos (metastases present in 2 cases were also identified). CT was correctly negative in 20/23 cases (a mass other than a pheo was detected in 3 patients); correctly positive in 12/12 adrenal and 4/5 extra-adrenal pheos and in 5/5 malignant pheos. Sensitivity, specificity and accuracy of scintigraphy and CT were 91% and 95.4%, 95.6% and 87%, 93.3% and 91.1% respectively (differences were not statistically significant). The overall data emphasize the complementary role of 123/131I-MIBG imaging and CT in the location of pheochromocytomas. A flow-chart essentially grounded on the combined use of both these diagnostic modalities is proposed which includes 123/131I-MIBG scintigraphy as a first choice examination.
为了明确间碘苄胍（MIBG）显像和CT在嗜铬细胞瘤（pheo）检测中的诊断作用，对45例疑似患有嗜铬细胞瘤且接受了这两种检查的患者的结果进行了分析和比较。闪烁扫描在23例中的22例结果正确为阴性，在12例肾上腺嗜铬细胞瘤中的11例、5例肾上腺外嗜铬细胞瘤中的5例以及5例恶性嗜铬细胞瘤中的4例结果正确为阳性（还发现了2例存在转移的病例）。CT在23例中的20例结果正确为阴性（3例患者检测到非嗜铬细胞瘤的肿块）；在12例肾上腺嗜铬细胞瘤中的12例、5例肾上腺外嗜铬细胞瘤中的4例以及5例恶性嗜铬细胞瘤中的5例结果正确为阳性。闪烁扫描和CT的敏感性、特异性和准确性分别为91%和95.4%、95.6%和87%、93.3%和91.1%（差异无统计学意义）。总体数据强调了123/131I-MIBG显像和CT在嗜铬细胞瘤定位中的互补作用。提出了一个主要基于这两种诊断方法联合使用的流程图，其中包括将123/131I-MIBG闪烁扫描作为首选检查。
