Braun M, Ney P, Hohlfeld T, Szymanski C, Bruch L, Schrör K
Institut für Pharmakologie, Heinrich-Heine-Universität Düsseldorf.
Vasa Suppl. 1991;33:337-8.
This study investigates the effects of 13,14-Dihydro-PGE1 (PGE0) in comparison to PGE1 on human platelets, human polymorphonuclear granulocytes (PMN) and a number of vessel preparations of different species. The potency of PGE0 in inhibition of platelet and neutrophil activation is similar to PGE1. The vascular action differs. At a comparable molar potency, PGE0 showed stronger contractile and less relaxing effects than PGE1. The biological activities of PGE0 may contribute to the in vivo effects of PGE1 in treatment of peripheral arterial occlusive disease, in particular at high-dose i.v. administration.
本研究调查了13,14-二氢前列地尔（PGE0）与前列地尔（PGE1）相比，对人血小板、人多形核粒细胞（PMN）以及多种不同物种血管制剂的影响。PGE0抑制血小板和中性粒细胞活化的效力与PGE1相似。其血管作用有所不同。在相当的摩尔效力下，PGE0比PGE1表现出更强的收缩作用和较弱的舒张作用。PGE0的生物学活性可能有助于PGE1在治疗外周动脉闭塞性疾病中的体内效应，尤其是在大剂量静脉给药时。
