Schecklmann Martin, Ehlis Ann-Christine, Plichta Michael M, Boutter Heike K, Metzger Florian G, Fallgatter Andreas J
University of Wuerzburg, Laboratory for Psychophysiology and Functional Imaging, Department of Psychiatry and Psychotherapy, 97080 Wuerzburg, Germany.
Psychiatry Res. 2007 Nov 15;156(2):129-38. doi: 10.1016/j.pscychresns.2007.01.009. Epub 2007 Sep 20.
Despite prominent prefrontal deficits and alterations in anatomy, neurophysiology, and neuropsychology after long-term alcohol consumption in alcohol dependent patients, only a few investigations of functional brain activity have been published. Using functional near-infrared spectroscopy (fNIRS), we examined the concentration changes in oxygenated (O(2)Hb) and deoxygenated (HHb) haemoglobin in 17 right-handed alcohol dependent patients after detoxification and 17 matched healthy controls during a verbal fluency task. Alcohol dependent patients were characterized by normal behavioural performance (number of words produced) and physiological activation patterns (increase of O(2)Hb and decrease of HHb) over frontotemporal regions during phonological and semantical verbal fluency. However, the degree of activation was diminished (lower magnitude of oxygenation) and the localization of the activation was more restricted to inferior frontal areas as compared with the healthy participants. fNIRS is a sensitive and valid method, to detect alterations in brain functioning in clinical groups like alcohol dependent patients. Altered prefrontal functional brain activation during verbal fluency in alcohol dependent patients in a detoxified state may precede behavioural or cognitive alterations with a later onset.
尽管酒精依赖患者长期饮酒后前额叶存在明显缺陷,且解剖结构、神经生理学和神经心理学发生改变,但关于功能性脑活动的研究报道却很少。我们使用功能性近红外光谱技术(fNIRS),检测了17名右手利的酒精依赖患者戒断后及17名匹配的健康对照者在言语流畅性任务期间氧合血红蛋白(O(2)Hb)和脱氧血红蛋白(HHb)的浓度变化。酒精依赖患者在语音和语义言语流畅性任务中,表现为正常的行为表现(产生的单词数量)和额颞叶区域的生理激活模式(O(2)Hb增加和HHb减少)。然而,与健康参与者相比,激活程度降低(氧合幅度较低),且激活定位更局限于额下区域。fNIRS是一种灵敏且有效的方法,可检测酒精依赖患者等临床群体的脑功能改变。处于戒断状态的酒精依赖患者在言语流畅性任务期间前额叶功能性脑激活改变可能先于行为或认知改变,而后两者出现较晚。