抗肿瘤坏死因子疗法对类风湿关节炎患者血脂水平的影响。
Effects of anti-tumor necrosis factor therapy on lipid profile in patients with rheumatoid arthritis.
作者信息
Soubrier Martin, Jouanel Pierre, Mathieu Sylvain, Poujol David, Claus Delphine, Dubost Jean Jacques, Ristori Jean Michel
机构信息
Service de Rhumatologie, Hôpital G. Montpied, Place Henri Dunant, BP 69, 63003 Clermont-Ferrand Cedex 1, France.
出版信息
Joint Bone Spine. 2008 Jan;75(1):22-4. doi: 10.1016/j.jbspin.2007.04.014. Epub 2007 Aug 27.
OBJECTIVES
Analyse the effects of anti-tumor necrosis factor therapy on serum levels of lipid in patients with rheumatoid arthritis (RA).
METHODS
Twenty-nine patients (26 females, 3 males) with established RA undergoing anti-TNF therapy (n=12, adalimumab; n=11, infliximab; n=6, etanercept) were recruited. Total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides (TG), and apolipoproteins (apo b and apo a) were assessed at baseline and after 14 weeks of treatment.
RESULTS
The disease activity index score (DAS(28)) was 5.19+/-0.90 and decreased to 3.46+/-0.97 at 16 weeks (p<0.001). There was no change neither in the levels of TC (5.65+/-0.98mmol/l vs 5.78+/-1.06mmol/l; p=0.43), TG (1.40+/-0.79mmol/l vs 1.45+/-0.67mmol/l; p=0.59), HDL-C (1.92+/-0.49mmol/l vs 1.97+/-0.49mmol/l; p=0.36), apo a1 (1.92+/-0.28g/l vs 1.99+/-0.29g/l; p=0.06), and LDL-C (3.41+/-0.91mmol/l vs 3.47+/-0.96mmol/l; p=0.66), nor in apo b (1.126+/-0.302g/l vs 1.13+/-0.28g/l; p=0.89), atherogenic index (3.13+/-1.05 vs 3.09+/-0.89; p=0.69) or the apo b/apo a1 ratio (0.58+/-0.25 vs 0.56+/-0.22; p=0.33).
CONCLUSION
The favourable effect of anti-tumor necrosis factor therapy on cardiovascular morbidity is not related to effects on lipid metabolism.
目的
分析抗肿瘤坏死因子疗法对类风湿关节炎（RA）患者血脂水平的影响。
方法
招募了29例确诊为RA且正在接受抗TNF治疗的患者（26例女性，3例男性）（12例使用阿达木单抗；11例使用英夫利昔单抗；6例使用依那西普）。在基线和治疗14周后评估总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、甘油三酯（TG）和载脂蛋白（载脂蛋白b和载脂蛋白a）。
结果
疾病活动指数评分（DAS(28)）为5.19±0.90，在16周时降至3.46±0.97（p<0.001）。总胆固醇（5.65±0.98mmol/l对5.78±1.06mmol/l；p=0.43）、甘油三酯（1.40±0.79mmol/l对1.45±0.67mmol/l；p=0.59）、高密度脂蛋白胆固醇（1.92±0.49mmol/l对1.97±0.49mmol/l；p=0.36）、载脂蛋白a1（1.92±0.28g/l对1.99±0.29g/l；p=0.06）、低密度脂蛋白胆固醇（3.41±0.91mmol/l对3.47±0.96mmol/l；p=0.66）水平，以及载脂蛋白b（1.126±0.302g/l对1.13±0.28g/l；p=0.89）、动脉粥样硬化指数（3.13±1.05对3.09±0.89；p=0.69）或载脂蛋白b/载脂蛋白a1比值（0.58±0.25对0.56±0.22；p=0.33）均无变化。
结论
抗肿瘤坏死因子疗法对心血管疾病发病率的有益作用与对脂质代谢的影响无关。
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