Qian Yezhou, Mao Menghui, Nian Feige
Department of Cardiology, The First Hospital of Jiaxing, The Affiliated Hospital of Jiaxing University, Jiaxing, China.
Department of Rheumatology, The First Hospital of Jiaxing, The Affiliated Hospital of Jiaxing University, Jiaxing, China.
Cardiol Res Pract. 2022 Aug 24;2022:6192053. doi: 10.1155/2022/6192053. eCollection 2022.
Tumor necrosis factor-alpha (TNF-) plays an important role in coronary heart disease (CHD), a chronic inflammatory process. Meanwhile, this pro-inflammatory factor is also involved in the pathogenesis of autoimmune diseases such as rheumatoid arthritis (RA). Patients with RA correspond to a higher risk of CHD. TNF- antagonist, one of the main treatments for RA, may reduce the risk of CHD in patients with RA. This review summarizes the pathogenesis of TNF- in CHD and discusses the relationship between TNF- antagonist and CHD in patients with RA.
肿瘤坏死因子-α（TNF-α）在冠心病（CHD）这一慢性炎症过程中发挥着重要作用。同时，这种促炎因子也参与类风湿关节炎（RA）等自身免疫性疾病的发病机制。RA患者患CHD的风险更高。TNF-α拮抗剂作为RA的主要治疗方法之一，可能会降低RA患者患CHD的风险。本综述总结了TNF-α在CHD中的发病机制，并探讨了TNF-α拮抗剂与RA患者CHD之间的关系。
