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Toll样受体识别配体的两种模式。

Two modes of ligand recognition by TLRs.

作者信息

Brodsky Igor, Medzhitov Ruslan

机构信息

Howard Hughes Medical Institute and Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.

出版信息

Cell. 2007 Sep 21;130(6):979-81. doi: 10.1016/j.cell.2007.09.009.

DOI:10.1016/j.cell.2007.09.009
PMID:17889640
Abstract

Toll-like receptors (TLRs) are membrane-bound sensors that detect and respond to microbial infection. Two studies in Cell, one in this issue, reveal how TLRs recognize their ligands. Kim et al. (2007) recently reported the structure of TLR4 bound to the accessory protein MD-2 and its antagonist, the drug eritoran. In this issue, Jin et al. (2007) describe the crystal structure of a complex between TLR1, TLR2, and a lipopeptide ligand.

摘要

Toll样受体（TLRs）是一类膜结合传感器，可检测并响应微生物感染。发表于《细胞》杂志的两项研究（其中一项就在本期）揭示了TLRs如何识别其配体。Kim等人（2007年）最近报道了与辅助蛋白MD-2及其拮抗剂药物依替膦酸结合的TLR4的结构。在本期中，Jin等人（2007年）描述了TLR1、TLR2与一种脂肽配体形成的复合物的晶体结构。

相似文献

[1]
Two modes of ligand recognition by TLRs.

Cell. 2007-9-21

[2]
Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide.

Cell. 2007-9-21

[3]
Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran.

Cell. 2007-9-7

[4]
Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer.

Immunity. 2009-12-18

[5]
Structures of the toll-like receptor family and its ligand complexes.

Immunity. 2008-8-15

[6]
Structural insights into pharmacophore-assisted in silico identification of protein-protein interaction inhibitors for inhibition of human toll-like receptor 4 - myeloid differentiation factor-2 (hTLR4-MD-2) complex.

J Biomol Struct Dyn. 2018-5-29

[7]
Human TLRs 10 and 1 share common mechanisms of innate immune sensing but not signaling.

J Immunol. 2010-3-26

[8]
Heterodimerization of TLR2 with TLR1 or TLR6 expands the ligand spectrum but does not lead to differential signaling.

J Leukoc Biol. 2008-3

[9]
Lipopeptides are signaled by Toll-like receptor 1, 2 and 6 in endolysosomes.

Int Immunol. 2014-10

[10]
CD14 directly binds to triacylated lipopeptides and facilitates recognition of the lipopeptides by the receptor complex of Toll-like receptors 2 and 1 without binding to the complex.

Cell Microbiol. 2006-12

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