DISC1对神经发生起到抑制作用。
DISC1 puts the brakes on neurogenesis.
作者信息
Dranovsky Alex, Hen Rene
机构信息
Departments of Psychiatry and Neuroscience, Columbia University, New York, NY 10032, USA.
出版信息
Cell. 2007 Sep 21;130(6):981-3. doi: 10.1016/j.cell.2007.09.004.
PMID:17889641
Abstract
The gene DISC1 (Disrupted-in-Schizophrenia 1) is a leading candidate gene for schizophrenia. In this issue, Duan et al. (2007) present evidence implicating DISC1 in the maturation and integration of newly generated neurons in the adult mouse hippocampus. Surprisingly, DISC1 appears to have opposite effects on neurogenesis during development and in adulthood.
摘要
DISC1基因（精神分裂症断裂基因1）是精神分裂症的主要候选基因。在本期中，段等人（2007年）提出证据表明DISC1基因与成年小鼠海马体中新生成神经元的成熟和整合有关。令人惊讶的是，DISC1基因在发育阶段和成年期对神经发生似乎具有相反的作用。
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