Lee Ya-Yun, Yang Shue-Fen, Ho Weng-Hang, Lee Yuan-Ho, Hung Shan-Ling
Institute of Clinical Dentistry, National Yang-Ming University, Taipei, Taiwan.
J Endod. 2007 Oct;33(10):1177-82. doi: 10.1016/j.joen.2007.05.011. Epub 2007 Jul 12.
Because eugenol is a major component of root canal sealers and retrograde filling materials, its effects on periapical bone healing are therefore of concern. In this study, the effects of eugenol on the activation of nuclear factor kappa B (NF-kappaB) and the expression of cyclooxygenase-2 (COX-2) in human osteoblasts were investigated. The results showed that eugenol activated the nuclear translocation of NF-kappaB. In addition, COX-2 protein expression in osteoblasts was induced by eugenol in a dose-dependent manner. Furthermore, the eugenol-modulated COX-2 expression was inhibited by an NF-kappaB inhibitor, N-acetylcysteine. Taken together, eugenol might induce COX-2 expression through the activation of NF-kappaB in human osteoblasts. These results suggest that eugenol might be involved in periapical healing by impairing the functions of osteoblasts.
由于丁香酚是根管封闭剂和倒充填材料的主要成分，因此其对根尖周骨愈合的影响备受关注。在本研究中，研究了丁香酚对人成骨细胞中核因子κB（NF-κB）激活和环氧合酶-2（COX-2）表达的影响。结果表明，丁香酚激活了NF-κB的核转位。此外，丁香酚以剂量依赖的方式诱导成骨细胞中COX-2蛋白表达。此外，NF-κB抑制剂N-乙酰半胱氨酸抑制了丁香酚调节的COX-2表达。综上所述，丁香酚可能通过激活人成骨细胞中的NF-κB诱导COX-2表达。这些结果表明，丁香酚可能通过损害成骨细胞功能参与根尖周愈合。
