Vaz de Campos Mireille Guimarães, Montesano Fábio Tadeu, Rodrigues Maria Madalena, Chauffaille Maria de Lourdes Lopes Ferrari
Disciplina de Hematologia e Hemoterapia, Universidade Federal de São Paulo, Escola Paulista de Medicina, Rua Botucatu, São Paulo, Brazil CEP 04023-900.
Cancer Genet Cytogenet. 2007 Oct 1;178(1):49-56. doi: 10.1016/j.cancergencyto.2007.06.013.
Poor outcomes of some chronic myeloid leukemia ((CML) patients have been associated with submicroscopic der(9q) deletions, particularly the 5'ABL region. Deletion profiles of 120 BCR/ABL+ CML patients were studied using the dual-fusion fluorescence in situ hybridization probe. Poor prognosis was associated with 5'ABL deletion but not with 3'BCR deletion. Overall survival (OS) and chronic phase duration (CPD) were significantly shorter for 5'ABL deletion than for those without deletions (OS time: 27 vs. 61 months, P = 0.02; CPD: 17 vs. 56 months, P = 0.02). In addition, when isolated 5'ABL deletion patients were compared to those without it, a greater impact on prognosis was detected (OS time: 18 vs. 59 months, P = 0.0008; CPD: 7 vs. 54 months, P = 0.0003). Isolated 5'ABL deletion seems to have a greater impact on survival than does concomitant 5'ABL and 3'BCR deletion, although the difference was not statistically significant in this aspect (OS time: 18 vs. 28 months, P = 0.08).
一些慢性髓性白血病（CML）患者的不良预后与亚显微水平的9号染色体长臂缺失（der(9q)）有关，尤其是5'ABL区域。使用双融合荧光原位杂交探针研究了120例BCR/ABL阳性CML患者的缺失图谱。预后不良与5'ABL缺失相关，而与3'BCR缺失无关。5'ABL缺失患者的总生存期（OS）和慢性期持续时间（CPD）明显短于无缺失患者（OS时间：27个月对61个月，P = 0.02；CPD：17个月对56个月，P = 0.02）。此外，将孤立的5'ABL缺失患者与无该缺失的患者进行比较时，发现对预后的影响更大（OS时间：18个月对59个月，P = 0.0008；CPD：7个月对54个月，P = 0.0003）。孤立的5'ABL缺失似乎比同时存在的5'ABL和3'BCR缺失对生存的影响更大，尽管在这方面差异无统计学意义（OS时间：18个月对28个月，P = 0.08）。
