中国儿童急性淋巴细胞白血病中ETV6-RUNX1融合基因的患病率
Prevalence of ETV6-RUNX1 fusion gene in children with acute lymphoblastic leukemia in China.
作者信息
Gao Yi-Jin, Zhu Xiao-Hua, Yang Yi, Wu Yue, Lu Feng-Juan, Zhai Xiao-Wen, Wang Hong-Sheng
机构信息
Division of Hematology/Oncology, Children's Hospital Fudan University, 183 Fenglin Road, Shanghai 200032, China.
出版信息
Cancer Genet Cytogenet. 2007 Oct 1;178(1):57-60. doi: 10.1016/j.cancergencyto.2007.05.019.
A series of 92 Chinese children newly diagnosed with acute lymphoblastic leukemia (ALL) were examined for the ETV6-RUNX1 (previously TEL-AML1) fusion gene by using a nested reverse transcriptase-polymerase chain reaction. ETV6-RUNX1 fusion transcripts were detected in 21 of 92 patients (22.8%): 16 with common ALL, 4 with precursor B-cell ALL, and 1 with T-ALL. The prevalence of ETV6-RUNX1 positivity was 24.7% (20/81) in childhood B-lineage ALL. The prevalence of ETV6-RUNX1 in Chinese pediatric ALL patients proved to be similar to that found in other countries.
采用巢式逆转录聚合酶链反应，对92例新诊断的中国儿童急性淋巴细胞白血病（ALL）患者进行ETV6-RUNX1（以前称为TEL-AML1）融合基因检测。92例患者中有21例（22.8%）检测到ETV6-RUNX1融合转录本：16例为普通ALL，4例为前体B细胞ALL，1例为T-ALL。儿童B系ALL中ETV6-RUNX1阳性率为24.7%（20/81）。中国儿童ALL患者中ETV6-RUNX1的发生率与其他国家相似。
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