一项关于非维生素、非矿物质补充剂使用情况的纵向研究：老年人群中的患病率、关联性及生存率

A longitudinal study of nonvitamin, nonmineral supplement use: prevalence, associations, and survival in an aging population.

作者信息

Knudtson Michael D, Klein Ronald, Lee Kristine E, Reinke Jennifer O, Danforth Lorraine G, Wealti Angela M, Moore Emily, Klein Barbara E K

机构信息

Department of Ophthalmology and Visual Sciences, University of Wisconsin, School of Medicine and Public Health, Madison, WI 53726-2336, USA.

出版信息

Ann Epidemiol. 2007 Dec;17(12):933-9. doi: 10.1016/j.annepidem.2007.07.098. Epub 2007 Sep 24.

DOI:10.1016/j.annepidem.2007.07.098

PMID:17890106

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2156191/

Abstract

PURPOSE

We sought to describe population and survival characteristics in nonvitamin, nonmineral (NVNM) supplement users in a population-based cohort study.

METHODS

People from 43 to 86 years of age living in Beaver Dam, Wisconsin, participated in a baseline examination from 1988 to 1990 (n = 4,926) and three follow-up examinations at 5-year intervals (n = 3,722, 2,962, 2,375 at each successive examination). Medication and supplement use, medical and lifestyle factors were collected during the examination and survival was monitored through 2002.

RESULTS

NVNM supplement use increased from 5% at baseline, to 6% at the second, to 21% at the third to 30% at the fourth examination. In general, younger age, vitamin or mineral use, and taking more medications was directly related to NVNM supplement use, while current smoking and history of other systemic diseases (e.g., cardiovascular disease, cancer) was inversely related to NVNM supplement use. After adjusting for age, sex, and other medical and lifestyle factors, users of NVNM supplements had lower mortality (hazard ratio, 0.74; 95% confidence interval, 0.57-0.95, p = 0.02) than nonusers.

CONCLUSIONS

NVNM supplement users had a healthier lifestyle and fewer co-morbid medical conditions and were more likely to survive after adjusting for these factors than non-users.

摘要

目的

在一项基于人群的队列研究中，我们试图描述非维生素、非矿物质（NVNM）补充剂使用者的人群特征和生存特征。

方法

居住在威斯康星州比弗代尔姆的43至86岁人群参与了1988年至1990年的基线检查（n = 4926），并每隔5年进行三次随访检查（每次连续检查的人数分别为n = 3722、2962、2375）。在检查期间收集药物和补充剂使用情况、医疗和生活方式因素，并监测至2002年的生存情况。

结果

NVNM补充剂的使用从基线时的5%增加到第二次检查时的6%，第三次检查时的21%，第四次检查时的30%。一般来说，年龄较小、使用维生素或矿物质以及服用更多药物与NVNM补充剂的使用直接相关，而当前吸烟和其他全身性疾病史（如心血管疾病、癌症）与NVNM补充剂的使用呈负相关。在调整年龄、性别以及其他医疗和生活方式因素后，NVNM补充剂使用者的死亡率低于非使用者（风险比，0.74；95%置信区间，0.57 - 0.95，p = 0.02）。