Kawazu Shin-ichiro, Komaki-Yasuda Kanako, Oku Hiroyuki, Kano Shigeyuki
National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, 2-13 Inada-cho, Obihiro, Hokkaido 080-8555, Japan.
Parasitol Int. 2008 Mar;57(1):1-7. doi: 10.1016/j.parint.2007.08.001. Epub 2007 Aug 24.
Malaria is one of the most debilitating and life threatening diseases in tropical regions of the world. Over 500 million clinical cases occur, and 2-3 million people die of the disease each year. Because Plasmodium lacks genuine glutathione peroxidase and catalase, the two major antioxidant enzymes in the eukaryotic cell, malaria parasites are likely to utilize members of the peroxiredoxin (Prx) family as the principal enzymes to reduce peroxides, which increase in the parasite cell due to metabolism and parasitism during parasite development. In addition to its function of protecting macromolecules from H(2)O(2), Prx has also been reported to regulate H(2)O(2) as second messenger in transmission of redox signals, which mediate cell proliferation, differentiation, and apoptosis. In the malaria parasite, several lines of experimental data have suggested that the parasite uses Prxs as multifunctional molecules to adapt themselves to asexual and sexual development. In this review, we summarize the accumulated knowledge on the Prx family with respect to their functions in mammalian cells and their possible function(s) in malaria parasites.
疟疾是世界热带地区最具衰弱性和威胁生命的疾病之一。每年发生超过5亿例临床病例，200万至300万人死于该疾病。由于疟原虫缺乏真核细胞中的两种主要抗氧化酶——真正的谷胱甘肽过氧化物酶和过氧化氢酶，疟原虫可能利用过氧化物酶（Prx）家族成员作为主要酶来还原过氧化物，这些过氧化物在寄生虫发育过程中因代谢和寄生作用而在寄生虫细胞中增加。除了具有保护大分子免受H₂O₂损伤的功能外，Prx还被报道在氧化还原信号传递中作为第二信使调节H₂O₂，氧化还原信号介导细胞增殖、分化和凋亡。在疟原虫中，多项实验数据表明，疟原虫将Prx用作多功能分子以适应无性和有性发育。在本综述中，我们总结了关于Prx家族在哺乳动物细胞中的功能及其在疟原虫中可能功能的累积知识。
