Amino Rogerio, Ménard Robert, Frischknecht Freddy
Unité de Biologie et Génétique du Paludisme and Grand Programme Horizontal Anopheles, Institut Pasteur, 25-28 Rue du Dr Roux, 75015 Paris, France.
Curr Opin Microbiol. 2005 Aug;8(4):407-14. doi: 10.1016/j.mib.2005.06.019.
A new view into the life of malaria parasites is now possible owing to recent advances in imaging techniques and to the generation of tagged parasites. Insights into how parasites interact with their insect vectors and mammalian hosts have been gained by the study of various parasitic forms in their natural environment. Quantitative analysis of Plasmodium ookinete motility has revealed different modes of motility in parasite invasion of the mosquito gut and the extrusion of invaded gut cells from the epithelium. Similar analysis with Plasmodium sporozoites has revealed the importance of parasite motility in transmission from the mosquito vector to the mammalian host.
由于成像技术的最新进展以及标记寄生虫的产生，现在有可能对疟原虫的生活有新的认识。通过研究自然环境中的各种寄生形式，人们对寄生虫如何与它们的昆虫媒介和哺乳动物宿主相互作用有了深入了解。对疟原虫动合子运动性的定量分析揭示了寄生虫侵入蚊子肠道以及从上皮细胞中挤出被侵入的肠道细胞时的不同运动模式。对疟原虫子孢子的类似分析揭示了寄生虫运动性在从蚊子媒介传播到哺乳动物宿主过程中的重要性。
