具有基质分化的基底细胞癌：β-连环蛋白[校正后]和骨桥蛋白的表达

Basal cell carcinoma with matrical differentiation: expression of beta-catenin [corrected] and osteopontin.

作者信息

Del Sordo Rachele, Cavaliere Antonio, Sidoni Angelo

机构信息

Department of Pathologic Anatomy and Histology, Division of Cancer Research, Perugia Medical School, University of Perugia, Italy.

出版信息

Am J Dermatopathol. 2007 Oct;29(5):470-4. doi: 10.1097/DAD.0b013e318156dceb.

DOI:10.1097/DAD.0b013e318156dceb

PMID:17890917

Abstract

Basal cell carcinoma with matrical differentiation is an extremely rare variant. To date, only 12 cases have been described in the literature. This tumor is a typical basal cell carcinoma with basaloid nests containing shadow cells identical to those of pilomatricoma and pilomatrical carcinoma. We present two additional cases and have investigated the immunoprofile of .-catenin and osteopontin with the aim of determining both their biological significance and possible diagnostic utility. The morphological and immunohistochemical features of these cases that we have found suggest that basal cell carcinomas with matrical differentiation belong to a spectrum of lesions deriving from hair follicles in which .-catenin plays an important role in the tumor development, differentiation, and behavior.

摘要

具有毛母质分化的基底细胞癌是一种极其罕见的变体。迄今为止，文献中仅描述了12例。该肿瘤是典型的基底细胞癌，其基底样巢中含有与毛母质瘤和毛母质癌相同的影细胞。我们报告另外2例，并研究了β-连环蛋白和骨桥蛋白的免疫表型，目的是确定它们的生物学意义和可能的诊断效用。我们发现的这些病例的形态学和免疫组化特征表明，具有毛母质分化的基底细胞癌属于源自毛囊的一系列病变，其中β-连环蛋白在肿瘤发生、分化和行为中起重要作用。