具有毛囊母质分化的基底细胞癌：一项β-连环蛋白分析的病例研究

Basal cell carcinoma with matrical differentiation: a case study with analysis of beta-catenin.

作者信息

Haskell Henry D, Haynes Harley A, McKee Phillip H, Redston Mark, Granter Scott R, Lazar Alexander J F

机构信息

Department of Pathology, Division of Dermatopathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

出版信息

J Cutan Pathol. 2005 Mar;32(3):245-50. doi: 10.1111/j.0303-6987.2005.00301.x.

DOI:10.1111/j.0303-6987.2005.00301.x

PMID:15701088

Abstract

Matrical differentiation in basal cell carcinoma (BCC) is rare. Only nine cases have been described that showed typical diagnostic features of BCC, in addition to shadow cells indicating hair-matrix differentiation. These cases often present a diagnostic challenge due to confusion with pilomatrixoma or pilomatrix carcinoma. We present a case of BCC with matrical differentiation in a 78-year-old man. Immunohistochemical and molecular methods are used to differentiate this lesion from benign or malignant forms of pilomatrixoma. differentiation: a case study with analysis of beta-catenin.

摘要

基底细胞癌（BCC）中的基质分化罕见。仅有9例被描述，除了显示毛基质分化的影子细胞外，还具有BCC的典型诊断特征。这些病例常因与毛母质瘤或毛母质癌混淆而带来诊断挑战。我们报告1例78岁男性的具有基质分化的BCC病例。采用免疫组化和分子方法将此病变与毛母质瘤的良性或恶性形式相鉴别。分化：β-连环蛋白分析的病例研究