ICI D1694, an inhibitor of thymidylate synthase for clinical study.
作者信息
Jackman A L, Jodrell D I, Gibson W, Stephens T C
机构信息
Drug Development Section, Institute of Cancer Research, Sutton, Surrey, UK.
出版信息
Adv Exp Med Biol. 1991;309A:19-23. doi: 10.1007/978-1-4899-2638-8_4.
PMID:1789205
Abstract
The TS inhibitor, ICI D1694, is a highly potent inhibitor of tumour growth in vitro and in vivo. Uptake via the RFC and rapid metabolism to polyglutamate forms appear to be responsible for potency. Antiproliferative toxicity in mice was evident although the dose-limiting renal toxicity experienced with CB3717 was not apparent.
摘要
Zotero 插件