Thaunat Olivier, Legendre Christophe, Morelon Emmanuel, Kreis Henry, Mamzer-Bruneel Marie-France
Centre de Recherche des Cordeliers, Université Pierre et Marie Curie, Paris, France.
Transplantation. 2007 Sep 27;84(6):671-6. doi: 10.1097/01.tp.0000282870.71282.ed.
Chronic allograft dysfunction is currently the main cause of late allograft failure. Recent encouraging evidence suggests that it may be possible to delay the development of graft damages if adequate management is initiated early in the course of the disease. These observations have renewed interest in the performance of protocol biopsies as routine follow-up procedure for the screening of renal transplants. In the present review, we summarize the available data from the literature to determine the pros and cons of protocol renal allograft biopsies. On the basis of this evidence, we discuss the ethical concerns raised by this procedure.
慢性移植肾失功是目前移植肾晚期失功的主要原因。最近有令人鼓舞的证据表明，如果在疾病进程早期就开始进行充分的管理，有可能延缓移植肾损害的发展。这些观察结果重新引发了人们对将方案活检作为肾移植常规随访程序以筛查移植肾的兴趣。在本综述中，我们总结了文献中的现有数据，以确定方案肾移植活检的利弊。基于这些证据，我们讨论了该程序引发的伦理问题。
