Rodriguez-Escudero M J, Prada de Medio E, Rosa Herranz C, Martinez Medina M C, Franquelo Gutierrez R
Unidad de Microbiología (Servicio de Análisis Clínicos), Hospital Virgen de la Luz, Cuenca.
Rev Esp Quimioter. 2007 Jun;20(2):203-5.
The aims were to assess the prevalence of resistances to antiretroviral drugs in HIV patients in the province of Cuenca and to determine the most frequently detected primary resistances. A total of 79 samples collected from April 2000 to July 2004 were analyzed. Resistance was detected using the genotypic technique VERSANTTM HIV1 (LiPA). Mutations more frequently found were M184V in the reverse transcriptase gene and V82A in the protease gene. The prevalence of primary resistances was 39.4%. Mutations more frequently detected were similar to those reported by other authors. The rate of primary resistance was higher than those found by other authors in Spain.
目的是评估昆卡省艾滋病毒患者对抗逆转录病毒药物的耐药性流行情况，并确定最常检测到的主要耐药性。对2000年4月至2004年7月期间收集的79份样本进行了分析。使用基因分型技术VERSANTTM HIV1（线性探针分析）检测耐药性。在逆转录酶基因中最常发现的突变是M184V，在蛋白酶基因中是V82A。主要耐药性的流行率为39.4%。更常检测到的突变与其他作者报道的相似。主要耐药率高于西班牙其他作者的发现。
