Fetal alcohol exposure and effects of LHRH and PMA on LH beta-mRNA expression in the female rat.

Fetal alcohol exposure (FAE) is associated with a variety of physiological and behavioral dysfunctions. Effects of FAE on reproduction have been described that include delayed puberty, altered gonadotrophin secretion and steroidogenesis, and altered sexual behavior. Earlier work suggested that pituitary function was compromised in adult fetal alcohol-exposed female rats. This study examined the effects of LHRH and PMA in vitro on LH beta-mRNA expression in pituitary fragments from FAE animals; a separate experiment examined the effects of estradiol-17 beta on LH beta-mRNA under similar conditions. The results indicate that the pituitary glands of FAE females have a reduced ability to respond to these three stimuli. The reason for this reduced responsiveness to LHRH, PMA, and estradiol-17 beta is not clear, but the alterations suggest that LH synthesis is impeded following fetal ethanol exposure.