氯氮䓬二钾与地西泮抗惊厥作用的比较。在恒河猴身上进行的为期四周的抗惊厥研究。
Comparison of anticonvulsant effects of clorazepate dipotassium and diazepam. Four week anticonvulsant study in Rhesus monkeys.
作者信息
Plotnikoff N P, O'Brien G S
机构信息
Department of Pharmacodynamics, Abbott Laboratories, North Chicago, Illinois 60064, USA.
出版信息
Dis Nerv Syst. 1974 Feb;35(2):87-90.
PMID:17894046
Abstract
Clorazepate dipotassium and diazepam were administered daily for the first 5 days of each week to Rhesus monkeys at equimolar doses and challanged once a week with a convulsant dose of pentylenetetrazol. Clorazepate exhibited sustained anticonvulsant activity throughout the second, third, and fourth weeks while diazepam was effective only during the second and third weeks.
摘要
在每周的前5天，以等摩尔剂量给恒河猴每日服用二钾氯氮䓬和地西泮，并每周一次用惊厥剂量的戊四氮进行激发试验。氯氮䓬在第二、第三和第四周均表现出持续的抗惊厥活性，而地西泮仅在第二和第三周有效。
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