Sato Kenta, Kaji Ryuji, Matsumoto Sadayuki, Nagahiro Shinji, Goto Satoshi
Department of Clinical Neuroscience, Institute of Health Biosciences, Graduate School of Medicine, University of Tokushima, Tokushima, Japan.
Mov Disord. 2007 Dec;22(16):2365-70. doi: 10.1002/mds.21732.
Topographical or compartmental involvement of the putamen and caudate nucleus has not been fully elucidated in multiple system atrophy predominantly presenting with Parkinsonism (MSA-P). We carried out immunohistochemical studies using antibodies to calbindin (CALB) and calcineurin (CaN) as neurochemical markers for striatal medium spiny neurons. We found that in the caudal and dorsolateral putamen, the area most affected in MSA-P, the medium spiny neurons positive for CALB were severely depleted, while CaN-positive neurons were relatively spared in a mosaic pattern. In the dorsal caudate nucleus, an area less affected in MSA, residual CALB-positive neurons exhibited a compartmentalized distribution that corresponded with the striosomal arrangement visualized by Met-enkephalin immunostaining. Our findings suggest that there is a compartmental difference in the susceptibility of striatal medium spiny neurons to neurodegeneration in MSA-P.
在以帕金森综合征为主的多系统萎缩（MSA-P）中，壳核和尾状核的局部或分区受累情况尚未完全阐明。我们使用针对钙结合蛋白（CALB）和钙调神经磷酸酶（CaN）的抗体进行免疫组织化学研究，将其作为纹状体中等棘状神经元的神经化学标记物。我们发现，在MSA-P中受影响最严重的尾侧和背外侧壳核区域，CALB阳性的中等棘状神经元严重减少，而CaN阳性神经元则以镶嵌模式相对保留。在背侧尾状核（MSA中受影响较小的区域），残留的CALB阳性神经元呈现出分区分布，这与甲硫氨酸脑啡肽免疫染色显示的纹状小体排列相对应。我们的研究结果表明，在MSA-P中，纹状体中等棘状神经元对神经退行性变的易感性存在分区差异。
