Horigane M, Ogihara K, Nakajima Y, Shinoda T, Taylor D
Graduate School of Life and Environmental Sciences, University of Tsukuba, Tennodai 1-1-1, Tsukuba, Ibaraki, Japan.
Insect Mol Biol. 2007 Oct;16(5):601-12. doi: 10.1111/j.1365-2583.2007.00754.x.
Molecular mechanisms of ecdysteroid regulation in development and reproduction have been thoroughly investigated in Diptera and Lepidoptera, but few studies report the molecular actions of ecdysteroids in hemimetabolous insects and more primitive arthropods. Ecdysteroids appear to be the main hormones regulating development and vitellogenesis in ticks. An ecdysteroid receptor that showed high homology with EcRs of other arthropods was isolated from Ornithodoros moubata (OmEcRA). OmEcR expression patterns coincided with ecdysteroid titres in the haemolymph during moulting and vitellogenesis and differed between mated and virgin females. Therefore, OmEcR appears to mediate the regulation of moulting and vitellogenesis by ecdysteroids in O. moubata females as seen in other arthropods.
在双翅目和鳞翅目中，蜕皮甾体在发育和繁殖过程中的调控分子机制已得到深入研究，但关于蜕皮甾体在半变态昆虫和更原始节肢动物中的分子作用的研究报道较少。蜕皮甾体似乎是蜱类发育和卵黄发生的主要调节激素。从莫氏钝缘蜱（OmEcRA）中分离出一种与其他节肢动物的蜕皮甾体受体（EcRs）具有高度同源性的蜕皮甾体受体。在蜕皮和卵黄发生过程中，OmEcR的表达模式与血淋巴中的蜕皮甾体滴度一致，且在交配雌蜱和未交配雌蜱之间存在差异。因此，与其他节肢动物一样，OmEcR似乎介导了莫氏钝缘蜱雌蜱中蜕皮甾体对蜕皮和卵黄发生的调控。
