Alexander L J, Macneil M D, Geary T W, Snelling W M, Rule D C, Scanga J A
U.S. Department of Agriculture-Agricultural Research Service, Miles City, MT 59301, USA.
Anim Genet. 2007 Oct;38(5):506-13. doi: 10.1111/j.1365-2052.2007.01643.x.
A whole-genome scan was conducted on 328 F(2) progeny in a Wagyu x Limousin cross to identify quantitative trait loci (QTL) affecting palatability and fatty acid composition of beef at an age-constant endpoint. We have identified seven QTL on five chromosomes involved in lipid metabolism and tenderness. None of the genes encoding major enzymes involved in fatty acid metabolism, such as fatty acid synthase (FASN), acetyl-CoA carboxylase alpha (ACACA), solute carrier family 2 (facilitated glucose transporter) member 4 (SLC2A4), stearoyl-CoA desaturase (SCD) and genes encoding the subunits of fatty acid elongase, was located in these QTL regions. The present study may lead to a better-tasting and healthier product for consumers through improved selection for palatability and lipid content of beef.
对328头和牛与利木赞牛杂交的F(2)后代进行了全基因组扫描，以确定在年龄恒定的终点影响牛肉适口性和脂肪酸组成的数量性状位点（QTL）。我们在五条染色体上鉴定出了七个参与脂质代谢和嫩度的QTL。参与脂肪酸代谢的主要酶的编码基因，如脂肪酸合酶（FASN）、乙酰辅酶A羧化酶α（ACACA）、溶质载体家族2（促进性葡萄糖转运蛋白）成员4（SLC2A4）、硬脂酰辅酶A去饱和酶（SCD）以及脂肪酸延长酶亚基的编码基因，均不在这些QTL区域。本研究可能通过改进对牛肉适口性和脂质含量的选择，为消费者带来口感更好、更健康的产品。
