超声检查结果与继续妊娠唐氏综合征胎儿决策的相关性
Association of ultrasound findings with decision to continue Down syndrome pregnancies.
作者信息
Perry Sandy, Woodall Angela L, Pressman Eva K
机构信息
Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Rochester, Rochester, NY, USA.
出版信息
Community Genet. 2007;10(4):227-30. doi: 10.1159/000106561.
OBJECTIVE
To evaluate the association of ultrasound findings and other factors with the decision to terminate trisomy-21-affected pregnancies.
METHODS
We performed a retrospective analysis of trisomy-21-affected pregnancies diagnosed prior to 24 weeks' gestation. Data were collected on maternal age, indications for prenatal diagnosis, gestational age at diagnosis, marital status, race, parity and ultrasound findings. Logistic regression, chi(2), t test and Fishers exact test were used for statistical analysis.
RESULTS
Fifty-nine pregnancies were identified with a termination rate of 72.9%. Termination rates were significantly lower in patients with major (50%) or minor (64%) ultrasound abnormalities than in patients with normal ultrasound exams (92%), p = 0.026 and 0.022, respectively. Patients who chose terminations were older (36.1 vs. 32.3), but this did not reach statistical significance (p = 0.059).
CONCLUSION
Patients with abnormal ultrasound results were more likely to continue a trisomy 21 pregnancy.
目的
评估超声检查结果及其他因素与终止21-三体综合征妊娠决策之间的关联。
方法
我们对妊娠24周前诊断为21-三体综合征的妊娠病例进行了回顾性分析。收集了产妇年龄、产前诊断指征、诊断时的孕周、婚姻状况、种族、产次及超声检查结果等数据。采用逻辑回归、卡方检验、t检验和费舍尔精确检验进行统计分析。
结果
共确定59例妊娠，终止妊娠率为72.9%。有严重（50%）或轻微（64%）超声异常的患者终止妊娠率显著低于超声检查正常的患者（92%），p值分别为0.026和0.022。选择终止妊娠的患者年龄较大（36.1岁对32.3岁），但未达到统计学显著性（p = 0.059）。
结论
超声检查结果异常的患者更有可能继续妊娠至21-三体胎儿出生。
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