轻度认知障碍患者海马体的质子磁共振波谱分析：一项初步研究。
Proton magnetic resonance spectroscopy of the hippocampus in patients with mild cognitive impairment: a pilot study.
作者信息
Franczak Malgorzata, Prost Robert W, Antuono Piero G, Mark Leighton P, Jones Jennifer L, Ulmer John L
机构信息
Departments of Neurology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
出版信息
J Comput Assist Tomogr. 2007 Sep-Oct;31(5):666-70. doi: 10.1097/RCT.0b013e318031bc31.
OBJECTIVE
To assess the brain metabolites in the hippocampus of patients with mild cognitive impairment (MCI) using proton magnetic resonance spectroscopy at 0.5 T.
METHODS
Absolute concentrations and ratios to creatine of N-acetyl aspartate, myoinositol, glutamate + glutamine, and choline were measured in the right and left hippocampus of 5 MCI patients and 5 control subjects.
RESULTS
In MCI subjects, reduced N-acetyl aspartate was found in the right hippocampus (P = 0.01), and increased myoinositol was found in the left hippocampus (P = 0.02). Myoinositol/N-acetyl aspartate ratios were higher in the right (P = 0.03) and left (P = 0.01) hippocampus of MCI subjects. No significant difference in the concentration of glutamate + glutamine was observed between the control and MCI groups.
CONCLUSIONS
An increase in myoinositol and a decrease in N-acetyl aspartate may be observed in the preclinical stages of dementia. Ratio measurements of these metabolites may serve as a biomarker for MCI.
目的
使用0.5T的质子磁共振波谱评估轻度认知障碍（MCI）患者海马体中的脑代谢物。
方法
测量了5例MCI患者和5例对照者左右海马体中N-乙酰天门冬氨酸、肌醇、谷氨酸+谷氨酰胺和胆碱的绝对浓度以及与肌酸的比率。
结果
在MCI受试者中，右侧海马体中N-乙酰天门冬氨酸减少（P = 0.01），左侧海马体中肌醇增加（P = 0.02）。MCI受试者右侧（P = 0.03）和左侧（P = 0.01）海马体中的肌醇/N-乙酰天门冬氨酸比率更高。对照组和MCI组之间谷氨酸+谷氨酰胺的浓度没有显著差异。
结论
在痴呆的临床前期阶段可能观察到肌醇增加和N-乙酰天门冬氨酸减少。这些代谢物的比率测量可能作为MCI的生物标志物。
Zotero 插件