Franczak Malgorzata, Prost Robert W, Antuono Piero G, Mark Leighton P, Jones Jennifer L, Ulmer John L
Departments of Neurology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
J Comput Assist Tomogr. 2007 Sep-Oct;31(5):666-70. doi: 10.1097/RCT.0b013e318031bc31.
To assess the brain metabolites in the hippocampus of patients with mild cognitive impairment (MCI) using proton magnetic resonance spectroscopy at 0.5 T.
Absolute concentrations and ratios to creatine of N-acetyl aspartate, myoinositol, glutamate + glutamine, and choline were measured in the right and left hippocampus of 5 MCI patients and 5 control subjects.
In MCI subjects, reduced N-acetyl aspartate was found in the right hippocampus (P = 0.01), and increased myoinositol was found in the left hippocampus (P = 0.02). Myoinositol/N-acetyl aspartate ratios were higher in the right (P = 0.03) and left (P = 0.01) hippocampus of MCI subjects. No significant difference in the concentration of glutamate + glutamine was observed between the control and MCI groups.
An increase in myoinositol and a decrease in N-acetyl aspartate may be observed in the preclinical stages of dementia. Ratio measurements of these metabolites may serve as a biomarker for MCI.
使用0.5T的质子磁共振波谱评估轻度认知障碍（MCI）患者海马体中的脑代谢物。
测量了5例MCI患者和5例对照者左右海马体中N-乙酰天门冬氨酸、肌醇、谷氨酸+谷氨酰胺和胆碱的绝对浓度以及与肌酸的比率。
在MCI受试者中，右侧海马体中N-乙酰天门冬氨酸减少（P = 0.01），左侧海马体中肌醇增加（P = 0.02）。MCI受试者右侧（P = 0.03）和左侧（P = 0.01）海马体中的肌醇/N-乙酰天门冬氨酸比率更高。对照组和MCI组之间谷氨酸+谷氨酰胺的浓度没有显著差异。
在痴呆的临床前期阶段可能观察到肌醇增加和N-乙酰天门冬氨酸减少。这些代谢物的比率测量可能作为MCI的生物标志物。
