Khazardoost S, Hantoushzadeh S, Khooshideh M, Borna S
Vali-e-asr Reproductive Health Research Center, Tehran University of Medical Sciences and Perinatology Department, Vali-e-asr Hospital, Tehran, Iran.
J Obstet Gynaecol. 2007 Aug;27(6):577-9. doi: 10.1080/01443610701469636.
Meconium aspiration syndrome (MAS) is a life-threatening respiratory disease in infants born through meconium stained amniotic fluid (MSAF). The purpose of this study was to determine risk factors for MAS in the newborns of mothers who had meconium stained amniotic fluid in labour. A retrospective study of all full-term pregnancies with MSAF from May 2003 to October 2004 was designed at a teaching hospital. Development of MAS was the primary outcome. Maternal details, mode of delivery and neonatal details (Apgar score, reassuring or non-reassuring fetal heart rate tracing and birth weight) were evaluated. During the study period, there were 2,603 deliveries of whom 302 (11.6%) had MSAF. MAS developed in 64 of these infants (21.1%). Compared with healthy neonates with MSAF, those with MAS had higher rate of non-reassuring fetal heart rate (FHR) tracing, thick meconium and Apgar score < or =5 at 5 min. The neonatal birth weight was lower in the MAS group, maternal age, parity, gestational age and mode of delivery were not significantly different in the two group. We found the severity of meconium, low Apgar score at 5 min and non-reassuring FHR tracing was associated with MAS in MSAF pregnancies.
胎粪吸入综合征（MAS）是一种发生于通过胎粪污染羊水（MSAF）出生的婴儿的危及生命的呼吸系统疾病。本研究的目的是确定分娩时羊水被胎粪污染的母亲所生新生儿患MAS的危险因素。在一家教学医院开展了一项对2003年5月至2004年10月所有足月妊娠且伴有MSAF病例的回顾性研究。MAS的发生是主要观察指标。对产妇的详细情况、分娩方式及新生儿详细情况（阿氏评分、胎儿心率监护结果正常或异常及出生体重）进行了评估。在研究期间，共分娩2603例，其中302例（11.6%）伴有MSAF。这些婴儿中有64例（21.1%）发生了MAS。与伴有MSAF的健康新生儿相比，患MAS的新生儿胎儿心率监护异常、胎粪黏稠及5分钟时阿氏评分≤5分的发生率更高。MAS组新生儿出生体重较低，两组产妇年龄、产次、孕周及分娩方式无显著差异。我们发现，在伴有MSAF的妊娠中，胎粪严重程度、5分钟时低阿氏评分及胎儿心率监护异常与MAS有关。
