Foo Thomas K F, Slavin Glenn S, Bluemke David A, Montequin Marcela, Hood Maureen N, Ho Vincent B
Magnetic Resonance Imaging Laboratory, GE Global Research, Niskayuna, New York, USA.
J Magn Reson Imaging. 2007 Oct;26(4):927-33. doi: 10.1002/jmri.21058.
To develop a method for fat suppression in myocardial delayed enhancement (MDE) studies that achieves effective signal intensity reduction in fat but does not perturb myocardial signal suppression.
A new approach to fat suppression that uses a spectrally-selective inversion-recovery (SPEC-IR) tip-up radio frequency (RF) pulse following the conventional nonselective IR RF pulse together with a second SPEC-IR RF pulse is proposed. The tip-up pulse restores the fat longitudinal magnetization after the nonselective IR pulse and allows the fat magnetization to recover more fully toward its equilibrium value, providing for better fat suppression by the second SPEC-IR RF pulse. This new approach was validated in phantom studies and in five patients.
Effective fat suppression was achieved using the proposed technique with minimal impact on normal myocardial signal suppression. Mean fat suppression achieved using this approach was 67% +/- 8%, as measured in the chest wall immediately opposite the heart.
The results indicate this modular-type approach optimizes fat suppression in myocardial delayed enhancement studies but does not perturb the basic IR pulse sequence or change basic acquisition parameters.
开发一种用于心肌延迟强化（MDE）研究的脂肪抑制方法，该方法能有效降低脂肪的信号强度，同时不干扰心肌信号抑制。
提出一种新的脂肪抑制方法，该方法在传统非选择性反转恢复（IR）射频（RF）脉冲之后使用一个频谱选择性反转恢复（SPEC-IR）上倾射频脉冲，并结合第二个SPEC-IR RF脉冲。上倾脉冲在非选择性IR脉冲之后恢复脂肪纵向磁化，并使脂肪磁化更充分地向其平衡值恢复，从而使第二个SPEC-IR RF脉冲能更好地抑制脂肪。这种新方法在模型研究和五名患者中得到验证。
使用所提出的技术实现了有效的脂肪抑制，对正常心肌信号抑制的影响最小。在心脏正对面的胸壁测量，使用该方法实现的平均脂肪抑制率为67%±8%。
结果表明，这种模块化方法优化了心肌延迟强化研究中的脂肪抑制，但不干扰基本的IR脉冲序列或改变基本采集参数。
