Ye Lianbao, Zhang Wanjin
Medicinal Chemistry Department, Guangdong Pharmaceutical University, Guangzhou, Guangdong, China.
Med Chem. 2007 Sep;3(5):466-8. doi: 10.2174/157340607781745465.
The new germanium compounds of cinnamic acid, RC(6)H(4)CHGe(OCH(2)CH(2))(3)NCH(2)COOH R=H (I), 2-OH (II), 3-OH (III), 4-OH (IV), have been obtained to study anti-tumor activities. Compounds (I-IV) were prepared by the electrophilic addition reaction and nucleophilic substitution reaction. Biological investigation has demonstrated that all compounds (I-IV) are lower toxicity with strongly anti-tumor activity than positive control.
