Neuschl J
Veterinärmedizinische Hochschule, Abteilung für Pharmakologie Kosice, Tschechoslowakei.
Arch Exp Veterinarmed. 1991;45(1):105-12.
40 adult White Californian rabbits were monitored for serum levels, soft tissue concentrations, and biological half-life of technical chlorotetracycline (Aureovit 12 C40 -- SPOFA), chlorotetracycline chloride (Farmitalia substance), tetracycline chloride (tetramyocine tablets for veterinary use -- SPOFA), and oxytetracycline chloride (oxymycoine in powder form for solution for veterinary use -- SPOFA), following application of 20 micrograms.kg-1. All tetracyclines tested were orally administered by gavage, following dissolution or suspension (Aureovit 12 C40). Statistically significant differences were found to exist among serum levels of various tetracyclines, with the 1st to 11th hours from administration, whereafter differences turned minimal between the 11th and 24th hours. Differences were found to exist also among concentrations in various organs.
对40只成年加利福尼亚白种兔子进行监测，在给予20微克/千克的剂量后，检测它们血清中强力金霉素（Aureovit 12 C40 - SPOFA）、盐酸金霉素（法玛西亚产品）、盐酸四环素（兽用四环素片 - SPOFA）和盐酸土霉素（兽用粉状氧四环素溶液 - SPOFA）的水平、软组织浓度以及生物半衰期。所有受试四环素均在溶解或悬浮（Aureovit 12 C40）后通过灌胃口服给药。发现不同四环素的血清水平之间存在统计学上的显著差异，给药后第1至11小时差异明显，此后第11至24小时差异变得最小。还发现不同器官中的浓度也存在差异。
