Demir Adalet, Altin Sedat, Pehlivan Davut, Demir Mulahim, Yakar Fatih, Seyhan Ekrem Cengiz, Dincer Seyyit Ibrahim
Yedikule Teaching Hospital for Chest Diseases and Thoracic Surgery, Depertmant of Thoracic Surgery, Istanbul, Turkey.
J Carcinog. 2007 Sep 26;6:13. doi: 10.1186/1477-3163-6-13.
Glutathione S-transferase (GSTs) plays an important role in the detoxification of many xenobiotics involved in the etiology of cancer. In different ethnic groups, variations in null allele frequency have been observed. We have investigated GSTM1 gene polymorphisms in healthy subjects and lung cancer patients in the Turkish population and reviewed the control subjects of the studies performed in the Turkish population.
Following blood sampling from patients and controls, DNA samples were extracted from the whole blood and were amplified by using polymerase chain reaction (PCR) method in all of the 256 cases, consisting of 102 previously diagnosed with lung cancer and 154 healthy controls.
The prevalence of GSTM1-null genotype in the lung cancer patients was 49%, compared to 52.6% in the control group (OR = 1.39, 95% CI = 0.70-1.90, p = 0.57). There were also no significant relationships in GSTM1 genotypes among histopathologic types of lung cancers (p > 0.05). The frequency of GSTM1 was found to be 41.2% (n = 1809) when the control subjects of the studies performed in Turkish population were reviewed.
We have observed that GSTM1 genotype is not an independent risk factor for lung cancer.
谷胱甘肽S-转移酶（GSTs）在许多与癌症病因相关的外源性物质的解毒过程中发挥着重要作用。在不同种族群体中，已观察到无效等位基因频率的差异。我们调查了土耳其人群中健康受试者和肺癌患者的GSTM1基因多态性，并回顾了在土耳其人群中进行的研究的对照受试者。
在对患者和对照进行采血后，从全血中提取DNA样本，并在所有256例病例中使用聚合酶链反应（PCR）方法进行扩增，其中包括102例先前诊断为肺癌的患者和154例健康对照。
肺癌患者中GSTM1无效基因型的患病率为49%，对照组为52.6%（OR = 1.39，95%CI = 0.70 - 1.90，p = 0.57）。肺癌组织病理学类型之间的GSTM1基因型也无显著相关性（p > 0.05）。回顾在土耳其人群中进行的研究的对照受试者时，发现GSTM1的频率为41.2%（n = 1809）。
我们观察到GSTM1基因型不是肺癌的独立危险因素。
