Wang Ning, Xu Xun, Zou Hai-dong, Zhu Jian-feng, Wang Wei-wei, Pan Ling
Department of Ophthalmology, First Affiliated Hospital of Shanghai Jiaotong University, Shanghai 200080, China.
Zhonghua Yan Ke Za Zhi. 2007 Jul;43(7):626-30.
To investigate the prevalence of diabetic retinopathy (DR) and diabetic macular edema (DME) in Beixinjing District, and analyze the image characteristics of their Optical coherence tomography (OCT), so as to evaluate the correlation among DME and the grade of DR as well as posterior vitreous detachment (PVD).
In a prospective study, OCT was performed in 151 eyes of 100 type 2 diabetes patients with DR and 102 normal eyes as control subjects.
795 cases were examined, and 215 of them were diagnosed to have DR. The average thickness of macular fovea was 195.56 microm in 151 eyes from 100 random sampling. 46 eyes had macular thickening. Three characteristics were found in the images of OCT in the patients with DME: sponge-like retinal swelling in 35 eyes (76.1%), macular cystoid edema in 8 eyes (17.4%), and serous retinal detachment in 3 eyes (6.5%). The statistical analysis showed that there was a positive correlation between the thickness of macular fovea and negative correlation with best-corrected visual acuity (r = 0.2869, P = 0.0004). There was statistic significance between the severity of DR and DME (P = 0.0003). But there was no statistic significance between DME and PVD.
The prevalence of DME is 37.1% in this district. Three type images of OCT were demonstrated in DME. The macular thickness is correlated with the severity of DR regardless of PVD.
调查北新泾地区糖尿病视网膜病变（DR）及糖尿病性黄斑水肿（DME）的患病率，分析其光学相干断层扫描（OCT）图像特征，以评估DME与DR分级及玻璃体后脱离（PVD）之间的相关性。
在一项前瞻性研究中，对100例患有DR的2型糖尿病患者的151只眼及作为对照的102只正常眼进行OCT检查。
共检查795例，其中215例被诊断为DR。随机抽取的100例患者的151只眼中黄斑中心凹平均厚度为195.56微米。46只眼有黄斑增厚。DME患者的OCT图像发现三种特征：35只眼（76.1%）呈海绵状视网膜肿胀，8只眼（17.4%）呈黄斑囊样水肿，3只眼（6.5%）呈浆液性视网膜脱离。统计分析显示，黄斑中心凹厚度与最佳矫正视力呈正相关（r = 0.2869，P = 0.0004）。DR严重程度与DME之间存在统计学意义（P = 0.0003）。但DME与PVD之间无统计学意义。
该地区DME患病率为37.1%。DME表现出三种OCT图像类型。无论有无PVD，黄斑厚度均与DR严重程度相关。
