[光动力疗法对病理性近视脉络膜新生血管的治疗效果]

[The therapeutic effects of photodynamic therapy on choroidal neovascularization of pathologic myopia].

作者信息

Zhang Mei-xia, Yan Mi, Zhang Jun-jun, Tang Jian, Wei Chun-yi, Meng Dan

机构信息

Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610041, China.

出版信息

Zhonghua Yan Ke Za Zhi. 2007 Jul;43(7):638-41.

PMID:17897555

Abstract

OBJECTIVE

To investigate the therapeutic effects and safety of photodynamic therapy on choroidal neovascularization (CNV) of pathologic myopia.

METHODS

Retrospective noncomparative clinical data of 27 cases with CNV complicated from pathologic myopia (32 eyes) and treated with PDT, the parameters including the study were fundus characteristics, fluorescein fundus angiography (FFA), optic coherence tomography (OCT), and best corrected visual acuity (BCVA) before and after PDT.

RESULTS

The mean age of 27 patients was 40.5. Five cases in the series were bilateral CNV. 29 eyes were subfoveal CNV and 3 eyes were juxtafoveal CNV. The degree of myopic was from -6D to -12D. At the final follow up, the improvement (increase >or= 2 lines) of BCVA was seen in 4 eyes (12.5%), vision acuity was stabilized (+/- 1 line) in 27 eyes (84.4%) and decreased (>or= 2 lines) in 1 eyes (3.1%). Metamorphopsia disappeared in 29 eyes (90.6%). FFA showed lacquer cracks in 12 eyes. CNV was completely closed in 17 eyes (53.1%), incompletely closed in 6 eyes (18.8% and partial closed in 9 eyes (28.1%) as demonstrated by FFA. The mean number of PDT treatment was 1.3 per eye in 27 cases. No serious local or systemic complications were encountered.

CONCLUSIONS

PDT is a safe and effective treatment for patients with CNV of pathologic myopia, it can reduce the risk of moderate and severe vision loss and alleviate the symptoms. PDT may improve the functional visual status of patients with pathologic myopia.

摘要

目的

探讨光动力疗法对病理性近视脉络膜新生血管（CNV）的治疗效果及安全性。

方法

回顾性分析27例病理性近视合并CNV患者（32只眼）接受光动力疗法治疗的临床资料，研究参数包括眼底特征、荧光素眼底血管造影（FFA）、光学相干断层扫描（OCT）以及光动力疗法前后的最佳矫正视力（BCVA）。

结果

27例患者的平均年龄为40.5岁。该系列中有5例为双侧CNV。29只眼为黄斑中心凹下CNV，3只眼为黄斑中心凹旁CNV。近视度数为-6D至-12D。在最后一次随访时，4只眼（12.5%）的BCVA得到改善（提高≥2行），27只眼（84.4%）视力稳定（±1行），1只眼（3.1%）视力下降（≥2行）。29只眼（90.6%）的视物变形消失。FFA显示12只眼有漆裂纹。FFA显示17只眼（53.1%）的CNV完全闭合，6只眼（18.8%）不完全闭合，9只眼（28.1%）部分闭合。27例患者每只眼接受光动力疗法治疗的平均次数为1.3次。未出现严重的局部或全身并发症。