Roy Angshumoy, Matzuk Martin M
Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX, USA.
Reprod Fertil Dev. 2007;19(7):783-91. doi: 10.1071/rd07090.
The germline is unique among tissues in being the only lineage that is transmitted through generations. The gonadal somatic cells that interact with male and female germ cells are equally important for their juxtacrine and paracrine signalling pathways that lead to the formation of functionally mature gametes and healthy progeny. The present review summarises exciting new studies that our group and others have achieved at the frontier of male and female germ cell biology and in studying transforming growth factor-beta signalling pathways in oocyte-somatic cell interactions and gonadal growth and differentiation. In the process, we have produced over 70 transgenic and knockout models to study reproduction in vivo. These models have helped us identify novel and unexplored areas of germ cell biology and translate this work into the fertility clinic.
生殖系在所有组织中独一无二,是唯一能代代相传的细胞谱系。与雄性和雌性生殖细胞相互作用的性腺体细胞,对于其旁分泌和自分泌信号通路同样重要,这些信号通路会导致功能成熟的配子形成和健康后代的产生。本综述总结了我们团队及其他团队在雄性和雌性生殖细胞生物学前沿,以及研究卵母细胞-体细胞相互作用、性腺生长和分化过程中转化生长因子-β信号通路方面所取得的令人兴奋的新研究成果。在此过程中,我们构建了70多个转基因和基因敲除模型来研究体内生殖过程。这些模型帮助我们识别出生殖细胞生物学中尚未探索的新领域,并将这项研究成果应用于生育诊所。