Coughlin Stephanie, Das Saugata, Lee Justin, Cooper John
Int J Cardiol. 2008 Oct 30;130(1):e34-6. doi: 10.1016/j.ijcard.2007.06.152. Epub 2007 Sep 25.
Cardiotoxicity is a recognised side effect of intravenous 5-fluorouracils. In the two case reports described we demonstrate similar cardiotoxic side effects seen with the use of capecitabine. With the increasing use of oral adjuvant chemotherapeutic agents, capecitabine should be used with caution in those patients with existing coronary artery disease.
心脏毒性是静脉注射5-氟尿嘧啶公认的副作用。在我们描述的两例病例报告中,我们证明了使用卡培他滨也会出现类似的心脏毒性副作用。随着口服辅助化疗药物使用的增加,对于已有冠状动脉疾病的患者,应谨慎使用卡培他滨。