Xiao Yong-Tao, Xiang Li-Xin, Shao Jian-Zhong
Institute of Cell Biology and Genetics, College of Life Sciences, Zhejiang University, Postal code: 310058, China.
Int J Biochem Cell Biol. 2008;40(10):2002-6. doi: 10.1016/j.biocel.2007.08.006. Epub 2007 Aug 22.
The vacuolar H(+)-ATPase (V-ATPase) is a universal component of eukaryotic organisms, which is present in both intracellular compartments and the plasma membrane. In the latter, its proton-pumping action creates the low intravacuolar pH, benefiting many processes such as, membrane trafficking, protein degradation, renal acidification, bone resorption, and tumor metastasis. In this article, we briefly summarize recent studies on the essential and diverse roles of mammalian V-ATPase and their medical applications, with a special emphasis on identification and use of V-ATPase inhibitors.
液泡H(+) -ATP酶（V-ATP酶）是真核生物的一种普遍成分，存在于细胞内区室和质膜中。在质膜中，其质子泵作用产生液泡内低pH值，有利于许多过程，如膜运输、蛋白质降解、肾脏酸化、骨吸收和肿瘤转移。在本文中，我们简要总结了关于哺乳动物V-ATP酶的重要和多样作用及其医学应用的最新研究，特别强调了V-ATP酶抑制剂的鉴定和使用。
