The Third Hospital Affiliated to Nantong University, Wuxi, Jiangsu, 214041, People's Republic of China.
Mol Biol Rep. 2010 Oct;37(7):3561-6. doi: 10.1007/s11033-010-0004-7. Epub 2010 Feb 25.
The vacuolar ATPase (V-ATPase) is a multisubunit enzyme that couples ATP hydrolysis to proton pumping across membranes. Recently, there is increasing evidence that V-ATPase may contribute to the pathogenesis of bone resorption disorders due to it is predominantly expressed in osteoclasts also function in bone resorption making it a good candidate in a therapeutic target for osteoporosis. Osteoclasts are capable of generating an acidic microenvironment necessary for bone resorption by utilizing V-ATPases to pump protons into the resorption lacuna. In addition, it has been shown that therapeutic interventions have been proposed that specifically target inhibition of the osteoclast proton pump. Modulation of osteoclastic V-ATPase activity has been considered to be a suitable therapy for the treatment of osteoporosis. All theses findings suggest that V-ATPase have important biological effects in bone resorption that might be a promising therapeutic target for osteoporosis. In this review, we will briefly discuss the biological features of osteoporosis and summarize recent advances on the role of V-ATPase in the pathogenesis and treatment of osteoporosis.
液泡型 ATP 酶（V-ATPase）是一种多亚基酶，可将 ATP 水解与质子跨膜泵出偶联。最近，越来越多的证据表明 V-ATPase 可能有助于骨吸收紊乱的发病机制，因为它主要在破骨细胞中表达，并且在骨吸收中起作用，使其成为骨质疏松症治疗靶点的良好候选物。破骨细胞能够通过利用 V-ATPase 将质子泵入吸收腔来产生骨吸收所需的酸性微环境。此外，已经表明已经提出了针对破骨细胞质子泵的抑制的治疗干预措施。调节破骨细胞 V-ATPase 活性被认为是治疗骨质疏松症的合适疗法。所有这些发现表明 V-ATPase 在骨吸收中具有重要的生物学效应，可能是骨质疏松症的有前途的治疗靶点。在这篇综述中，我们将简要讨论骨质疏松症的生物学特征，并总结 V-ATPase 在骨质疏松症发病机制和治疗中的作用的最新进展。
