Fan Ying, Wu Shuo-Dong, Fu Bei-Bei
Department of General Surgery, Second Affiliated Hospital (Shengjing Hospital), China Medical University, Shenyang 110004, China.
Hepatobiliary Pancreat Dis Int. 2007 Oct;6(5):513-5.
The effect of "intestinal transit" has become a new field of interest in the study of the pathogenesis of cholesterol gallstones. This study was undertaken to further test this notion and ascertain the relationship between impaired intestinal transit function and cholesterol gallstones.
A total of 64 hamsters were divided into 2 groups, experimental and control. Each was subdivided into 4 subgroups for sacrifice at different time. A high-cholesterol diet and a standard diet were fed to each group. The geometric center, which represents the intestinal transit function was calculated.
The growth of all hamsters was normal. Cholesterol gallstones were found in 2 hamsters at the end of the 4th week. The geometric center values for the experimental and control groups were 2.3891+/-0.3923 vs. 2.7730+/-0.5283, at the end of week 3; 1.8148+/-0.4312 vs. 3.2294+/-1.1613 at week 4; 1.8451+/-0.3700 vs. 2.9075+/-0.3756 at week 5; and 1.8025+/-0.3413 vs. 3.0920+/-0.5622 at week 6.
A high cholesterol diet can significantly reduce the intestinal transit function and facilitate the formation of cholesterol gallstones.
“肠道转运”的影响已成为胆固醇胆结石发病机制研究中的一个新的关注领域。本研究旨在进一步验证这一观点，并确定肠道转运功能受损与胆固醇胆结石之间的关系。
总共64只仓鼠被分为两组，实验组和对照组。每组再细分为4个亚组，以便在不同时间处死。给每组喂食高胆固醇饮食和标准饮食。计算代表肠道转运功能的几何中心。
所有仓鼠生长正常。在第4周结束时，2只仓鼠发现有胆固醇胆结石。实验组和对照组在第3周结束时的几何中心值分别为2.3891±0.3923和2.7730±0.5283；第4周时为1.8148±0.4312和3.2294±1.1613；第5周时为1.8451±0.3700和2.9075±0.3756；第6周时为1.8025±0.3413和3.0920±0.5622。
高胆固醇饮食可显著降低肠道转运功能，并促进胆固醇胆结石的形成。
