Venkatasubramanian Ganesan, Chittiprol Seetharamaiah, Neelakantachar Narendran, Naveen Magadi N, Thirthall Jagadisha, Gangadhar Bangalore N, Shetty K Taranath
Department of Psychiatry, National Institute of Mental Health and Neuro Sciences, Bangalore 560029, Karnataka, India.
Am J Psychiatry. 2007 Oct;164(10):1557-60. doi: 10.1176/appi.ajp.2007.07020233.
The purpose of this study was to examine the evidence for the insulin-like growth factor-1 (IGF-1) deficiency hypothesis in the pathogenesis of schizophrenia.
The authors examined the fasting plasma levels of glucose, insulin, IGF-1, and cortisol in antipsychotic-naive schizophrenia patients (N=44) relative to age- and sex-matched healthy comparison subjects (N=44). Patients and comparison subjects were also matched for anthropometric measures and physical activity.
Schizophrenia patients had a significantly higher mean plasma insulin level as well as a significantly higher mean insulin resistance score relative to healthy comparison subjects. The mean plasma IGF-1 level was significantly lower in patients. IGF-1 levels had a significant negative correlation with plasma insulin levels. The total positive symptoms score as well as the hallucinations subscore had a significant inverse relationship with IGF-1 levels.
Deficient IGF-1 might underlie insulin resistance in schizophrenia. The IGF-1 deficit in antipsychotic-naive schizophrenia patients and its significant correlation with psychopathology scores suggest that IGF-1 might be potentially involved in the pathogenesis of schizophrenia.
本研究旨在检验胰岛素样生长因子-1（IGF-1）缺乏假说在精神分裂症发病机制中的证据。
作者检测了未服用抗精神病药物的精神分裂症患者（N = 44）相对于年龄和性别匹配的健康对照受试者（N = 44）的空腹血浆葡萄糖、胰岛素、IGF-1和皮质醇水平。患者和对照受试者在人体测量指标和身体活动方面也进行了匹配。
与健康对照受试者相比，精神分裂症患者的平均血浆胰岛素水平显著更高，平均胰岛素抵抗评分也显著更高。患者的平均血浆IGF-1水平显著更低。IGF-1水平与血浆胰岛素水平呈显著负相关。总的阳性症状评分以及幻觉子评分与IGF-1水平呈显著负相关。
IGF-1缺乏可能是精神分裂症患者胰岛素抵抗的基础。未服用抗精神病药物的精神分裂症患者的IGF-1缺乏及其与精神病理学评分的显著相关性表明，IGF-1可能潜在参与了精神分裂症的发病机制。
