Reynish E, Cortes F, Andrieu S, Cantet C, Olde Rikkert M, Melis R, Froelich L, Frisoni G B, Jönsson L, Visser P J, Ousset P J, Vellas B
Inserm, U558, Toulouse, France.
Neuroepidemiology. 2007;29(1-2):29-38. doi: 10.1159/000108915. Epub 2007 Sep 24.
The long-term objective of the ICTUS study is to identify milestones in Alzheimer's disease (AD) progression and to develop a model to predict disease course in individual AD patients in Europe. The secondary objectives are to describe the patterns of prescribing, and the socioeconomic impact of AD in Europe. Between 2003 and 2005 1,380 patients with probable AD were recruited in specialised (secondary care) clinics in 12 European countries. Their mean age was 76 years and they had a mean of 8.0 +/- (SD) 4.6 years of education. Thirty-five percent were male. The mean MMSE score was 20.4 +/- (SD) 4.0. Forty-three percent had very mild dementia (CDR 0.5) and 44% had mild dementia (CDR 1). All patients completed baseline evaluation and biannual follow-up is ongoing. The goals of the current study are to describe the specific methods for recruitment in this crosscultural setting and the characteristics of the inception ICTUS cohort, including clinical features, co-morbidity, neuropsychological performance, neuropsychiatric symptoms, functional impairment and social burden.
ICTUS研究的长期目标是确定阿尔茨海默病（AD）进展中的里程碑事件，并开发一个模型来预测欧洲个体AD患者的病程。次要目标是描述欧洲AD的处方模式以及社会经济影响。2003年至2005年期间，在欧洲12个国家的专科（二级护理）诊所招募了1380例可能患有AD的患者。他们的平均年龄为76岁，平均受教育年限为8.0 +/-（标准差）4.6年。35%为男性。平均MMSE评分为20.4 +/-（标准差）4.0。43%患有极轻度痴呆（CDR 0.5），44%患有轻度痴呆（CDR 1）。所有患者均完成了基线评估，目前正在进行每年两次的随访。本研究的目的是描述在这种跨文化背景下的具体招募方法以及初始ICTUS队列的特征，包括临床特征、合并症、神经心理学表现、神经精神症状、功能障碍和社会负担。
